Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAGS (Q8N159) - Overview - Molecular Target Synopsis

Protein


NAGS, N-acetylglutamate synthase, mitochondrial
Enzyme Classification 2.3.1.1
UniProt Q8N159

Also Known as NAGS_HUMAN, NAGS

Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. Homodimer. Homotetramer.

4K30
STRUCTURE OF THE N-ACETYLTRANSFERASE DOMAIN OF HUMAN N-ACETYLGLUTAMATE SYNTHASE
RCSB/PDB
Inspect Structure
See all 3D Structures for NAGS

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
534ENSG00000161653ENST00000293404ENSP00000293404Q8N159-1
511ENSG00000161653ENST00000589767ENSP00000465408

Sub-cellular localization


UniProt: NAGS is active in the following subcellular-locations: mitochondrion matrix.
GO terms: NAGS is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAGS has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, HCC_2998, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LOX-IMVI, JHH-7, NCI-H920

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For NAGS there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis