Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCA6 (Q8N139) - Overview - Molecular Target Synopsis


ABCA6, ATP-binding cassette sub-family A member 6
UniProt Q8N139

Also Known as ABCA6_HUMAN, ABCA6

Probable transporter which may play a role in macrophage lipid homeostasis.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: ABCA6 is active in the following subcellular-locations: membrane.
GO terms: ABCA6 is active in the following subcellular-locations: integral component of membrane, intracellular membrane-bounded organelle, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCA6 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-10, TMD8, RI-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, hMSC-AT, SK-N-SH

(see details)

3D Structures

At greater than 35% identity similarity to ABCA6 there are:
4 structures (6 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ABCA6 has been screened with compounds ( bioactivities). (see details)