Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FUK (Q8N0W3) - Overview - Molecular Target Synopsis

Protein


FUK, L-fucose kinase
Enzyme Classification 2.7.1.52
UniProt Q8N0W3

Also Known as FUK_HUMAN, FUK

Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: FUK is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FUK has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, T47D, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-361, YMB-1, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

RNA Interference


FUK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SMOV2, SUM149. (see details)