Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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(Q8KLK7) - Overview - Molecular Target Synopsis

Protein


, (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
Enzyme Classification 1.13.11.80
UniProt Q8KLK7

Also Known as DPGC_STRTO

Involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. Catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. DpgC performed a net four-electron oxidation of the benzylic carbon of DPA-CoA and the hydrolysis of the thioester bond to generate free CoA (PubMed:18004875, PubMed:17507985). DpgC has the ability to process a diverse range of substituted phenylacetyl-CoA substrates (PubMed:18004875). Homohexamer; dimer of trimers.

5KAG
CRYSTAL STRUCTURE OF A DIOXYGENASE IN THE CROTONASE SUPERFAMILY IN P21
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
438Q8KLK7-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
6 structures (54 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis