Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA7 (Q8IZY2) - Overview - Molecular Target Synopsis

Protein


ABCA7, ATP-binding cassette sub-family A member 7
UniProt Q8IZY2

Also Known as ABCA7_HUMAN, ABCA7

Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA7 is active in the following subcellular-locations: cell membrane, cell projection, cytoplasm, early endosome membrane, endoplasmic reticulum, golgi apparatus membrane, phagocytic cup, ruffle membrane.
GO terms: ABCA7 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, cell junction, cell surface, early endosome membrane, endoplasmic reticulum, glial cell projection, Golgi apparatus, Golgi membrane, integral component of membrane, intracellular membrane-bounded organelle, phagocytic cup, plasma membrane, ruffle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA7 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, IGROV1, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H929, TMD8, NCI-H1781

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, CD20-positive B cell

(see details)

3D Structures


At greater than 50% identity similarity to ABCA7 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA7 has been screened with compounds ( bioactivities). (see details)