ABCA7 (Q8IZY2) - Overview - Molecular Target Synopsis
ABCA7, ATP-binding cassette sub-family A member 7
Also Known as ABCA7_HUMAN, ABCA7
Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|2146||ENSG00000064687||ENST00000263094, ENST00000433129||ENSP00000263094, ENSP00000414062||Q8IZY2-1|
UniProt: ABCA7 is active in the following subcellular-locations: cell membrane, cell projection, cytoplasm, early endosome membrane, endoplasmic reticulum, golgi apparatus membrane, phagocytic cup, ruffle membrane.
GO terms: ABCA7 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, cell junction, cell surface, early endosome membrane, endoplasmic reticulum, glial cell projection, Golgi apparatus, Golgi membrane, integral component of membrane, intracellular membrane-bounded organelle, phagocytic cup, plasma membrane, ruffle membrane.