Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDK20 (Q8IZL9) - Overview - Molecular Target Synopsis

Protein


CDK20, Cyclin-dependent kinase 20
Enzyme Classification 2.7.11.22
UniProt Q8IZL9

Also Known as CDK20_HUMAN, CDK20, CCRK, CDCH

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CDK20 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, nucleus.
GO terms: CDK20 is active in the following subcellular-locations: cilium, cytoplasm, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDK20 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-21H, HCC364, NCI-H1882

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


CDK20 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, CAOV3. (see details)

3D Structures


At greater than 35% identity similarity to CDK20 there are:
211 structures (250 chains) solved
199 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CDK20 is solved in complex with the approved drug(s):

B49/SUNITINIB (3TI1_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDK20 has been screened with compounds ( bioactivities). (see details)