CDK20 (Q8IZL9) - Overview - Molecular Target Synopsis
CDK20, Cyclin-dependent kinase 20
Enzyme Classification 188.8.131.52
Also Known as CDK20_HUMAN, CDK20, CCRK, CDCH
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.
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UniProt: CDK20 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, nucleus.
GO terms: CDK20 is active in the following subcellular-locations: cilium, cytoplasm, nucleoplasm, nucleus.