Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CDK20 (Q8IZL9) - Overview - Molecular Target Synopsis


CDK20, Cyclin-dependent kinase 20
Enzyme Classification
UniProt Q8IZL9

Also Known as CDK20_HUMAN, CDK20, CCRK, CDCH

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CDK20 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, nucleus.
GO terms: CDK20 is active in the following subcellular-locations: cilium, cytoplasm, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CDK20 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-21H, HCC364, NCI-H1882

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference

CDK20 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, CAOV3. (see details)

3D Structures

At greater than 35% identity similarity to CDK20 there are:
210 structures (250 chains) solved
197 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CDK20 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CDK20 has been screened with 37 compounds (76 bioactivities). (see details)