Molecular Target Synopsis
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Druggability
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MCOLN2 (Q8IZK6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed10
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria10


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
6HRS_C Mucolipin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 69.1 35.7 Yes Yes
2 empty 2.24 64.4 29.8 No No
3 empty 1.7 64.4 26.4 No No
4 empty 2.21 62.5 18.6 No No
5 empty 1.98 62.2 20 No No
6 empty 2.41 68.4 19.9 No No
7 empty 2.33 65.3 14.2 No No
8 empty 2.6 64.8 25.2 No No
9 empty 2.33 73.3 10.3 No No
10 empty 1.9 61.3 10.8 No No
6HRS_B Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.4 34.4 Yes No
2 empty 2.35 65.8 38.6 No No
3 empty 1.85 66.7 19.6 No No
4 empty 2.08 62.6 14.8 No No
5 empty 2.31 66.4 14 No No
6 empty 2.73 54.4 18.8 No No
7 empty 2.08 62.3 14 No No
8 empty 2.32 67.6 14.2 No No
9 empty 2.06 74.6 12 No No
10 empty 2.31 61.9 16.6 No No
6HRS_A Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 65.7 37.8 Yes No
2 empty 2.66 68 25.9 No No
3 empty 1.82 63.5 27.6 No No
4 empty 2.18 63.9 17.9 No No
5 empty 1.92 62.4 20.6 No No
6 empty 2.51 63.2 15.9 No No
7 empty 2.51 63.1 25.6 No No
8 empty 2.35 75.2 8.7 No No
9 empty 2.1 75.6 10.1 No No
10 empty 2.13 68.7 13.6 No No
6HRS_H Mucolipin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 66.9 33.7 Yes Yes
2 empty 2.25 59.1 29.6 No No
3 empty 1.81 68.5 17.5 No No
4 empty 2.48 60.8 25.5 No No
5 empty 2.08 63.6 18.7 No No
6 empty 2.35 71.4 13.2 No No
7 empty 2.09 72.6 14.1 No No
8 empty 2.3 63.7 11.2 No No
9 empty 2.01 63.9 10.9 No No
10 empty 2.37 52.2 14.3 No No
6HRR_B Mucolipin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 66.8 33.2 Yes Yes
2 empty 1.95 64.6 25.5 No No
3 bound 2.35 67.9 18.8 No No
4 bound 2.31 71.5 13.1 No No
5 empty 2.36 66.6 16.2 No No
6 empty 2.43 56.5 19.3 No No
7 bound 2.67 70.1 12 No No
8 empty 2.03 72.2 14.5 No No
9 empty 1.93 68.3 11.6 No No
10 empty 2.38 62.6 9.7 No No
6HRR_A Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 66.4 28 Yes No
2 empty 2.03 65.6 24 No No
3 empty 2.31 62.9 24.6 No No
4 bound 2.35 65.5 15.3 No No
5 empty 2.56 60.7 15.7 No No
6 bound 2.51 60.9 21.2 No No
7 empty 2.21 74.9 9.1 No No
8 empty 2.06 74.5 12.9 No No
9 empty 2.16 63.4 15.4 No No
10 empty 2.2 58.2 17.3 No No
6HRS_G Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 70.3 29.8 Yes No
2 empty 1.77 66.6 21.8 No No
3 empty 2.13 66.4 24.1 No No
4 empty 2.03 61.6 25.5 No No
5 empty 2.04 64.4 19.1 No No
6 empty 2.28 70.3 16.9 No No
7 empty 2.49 64.7 23.8 No No
8 empty 2.18 63.9 13.8 No No
9 empty 2.35 72.1 12.9 No No
10 empty 2.48 69.6 15.2 No No
6HRS_E Mucolipin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 66.6 37.7 Yes Yes
2 empty 1.84 66.3 19.2 No No
3 empty 2.04 63.9 18.9 No No
4 empty 2.32 56.5 17.4 No No
5 empty 2.6 61.8 25.1 No No
6 empty 2.2 64.4 11.9 No No
7 empty 2.22 71.8 11 No No
8 empty 2.19 61.5 16.6 No No
9 empty 2.08 77.1 9.6 No No
10 empty 2.24 68.5 14 No No
6HRS_D Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 64.8 35.2 Yes No
2 empty 2.26 65.2 20.7 No No
3 empty 1.83 66.4 18.2 No No
4 empty 1.92 64.9 20.9 No No
5 empty 2 68.5 20.4 No No
6 empty 2.01 57 20.8 No No
7 empty 2.3 69.9 12.1 No No
8 empty 2.36 64.4 14.7 No No
9 empty 2.32 60.7 14.6 No No
10 empty 2.17 69.5 10.9 No No
6HRS_F Mucolipin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.28 68 24.5 Yes No
2 empty 1.85 64 26 No No
3 empty 2.2 65.8 32.1 No No
4 empty 2.39 67.6 18.8 No No
5 empty 2.3 67.4 13.1 No No
6 empty 2.47 61.6 23.4 No No
7 empty 1.94 70.1 13.9 No No
8 empty 2.13 72.3 11.8 No No
9 empty 2.07 76.9 13.7 No No
10 empty 2.33 62.9 13.2 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score