MCOLN2 (Q8IZK6) - Overview - Molecular Target Synopsis
Also Known as MCLN2_HUMAN, MCOLN2
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Forms homooligomeric complexes; probably tetrameric (By similarity). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). Interacts with TMEM176A (PubMed:25130899).
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UniProt: MCOLN2 is active in the following subcellular-locations: cell membrane, late endosome membrane, lysosome membrane, recycling endosome membrane.
GO terms: MCOLN2 is active in the following subcellular-locations: integral component of membrane, late endosome membrane, lysosome, plasma membrane, recycling endosome membrane.