Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MCOLN2 (Q8IZK6) - Overview - Molecular Target Synopsis

Protein


MCOLN2, Mucolipin-2
UniProt Q8IZK6

Also Known as MCLN2_HUMAN, MCOLN2

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Forms homooligomeric complexes; probably tetrameric (By similarity). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). Interacts with TMEM176A (PubMed:25130899).

6HRS
STRUCTURE OF THE TRPML2 ELD AT PH 4.5
RCSB/PDB
Inspect Structure
See all 3D Structures for MCOLN2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MCOLN2 is active in the following subcellular-locations: cell membrane, late endosome membrane, lysosome membrane, recycling endosome membrane.
GO terms: MCOLN2 is active in the following subcellular-locations: integral component of membrane, late endosome membrane, lysosome, plasma membrane, recycling endosome membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MCOLN2 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, SK_MEL_2, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, OCI-LY-10, CCRF-SB

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)

3D Structures


For MCOLN2 there are:
2 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MCOLN2 has been screened with compounds ( bioactivities). (see details)