Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MCOLN2 (Q8IZK6) - Overview - Molecular Target Synopsis


MCOLN2, Mucolipin-2
UniProt Q8IZK6

Also Known as MCLN2_HUMAN, MCOLN2

Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Forms homooligomeric complexes; probably tetrameric (By similarity). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific (PubMed:19885840). Interacts with TMEM176A (PubMed:25130899).

Inspect Structure
See all 3D Structures for MCOLN2

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MCOLN2 is active in the following subcellular-locations: cell membrane, late endosome membrane, lysosome membrane, recycling endosome membrane.
GO terms: MCOLN2 is active in the following subcellular-locations: integral component of membrane, late endosome membrane, lysosome, plasma membrane, recycling endosome membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MCOLN2 has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_28, SK_MEL_2, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, OCI-LY-10, CCRF-SB

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, SK-N-SH, NHLF

(see details)

3D Structures

For MCOLN2 there are:
2 structures (10 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

MCOLN2 has been screened with compounds ( bioactivities). (see details)