Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TDH (Q8IZJ6) - Overview - Molecular Target Synopsis

Protein


TDH, Inactive L-threonine 3-dehydrogenase, mitochondrial
UniProt Q8IZJ6

Also Known as TDH_HUMAN, TDH, SDR14E1P

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
230Q8IZJ6-1
180Q8IZJ6-2
157Q8IZJ6-3

Sub-cellular localization


UniProt: TDH is active in the following subcellular-locations: mitochondrion.
GO terms: TDH is active in the following subcellular-locations: mitochondrial inner membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TDH has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LN-18, A-375

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

RNA Interference


TDH was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


At greater than 75% identity similarity to TDH there are:
3 structures (24 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis