Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCYL3 (Q8IZE3) - Overview - Molecular Target Synopsis

Protein


SCYL3, Protein-associating with the carboxyl-terminal domain of ezrin
UniProt Q8IZE3

Also Known as PACE1_HUMAN, SCYL3, PACE1

May play a role in regulating cell adhesion/migration complexes in migrating cells. Interacts with EZR/VIL2 C-terminal domain.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SCYL3 is active in the following subcellular-locations: cell projection, cytoplasm, golgi apparatus, lamellipodium.
GO terms: SCYL3 is active in the following subcellular-locations: cytoplasm, Golgi apparatus, lamellipodium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCYL3 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, T47D, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-175-VII, YMB-1, ZR-75-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, GM12878

(see details)

RNA Interference


SCYL3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB436, HUO9. (see details)