Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RASEF (Q8IZ41) - Overview - Molecular Target Synopsis

Protein


RASEF, Ras and EF-hand domain-containing protein
UniProt Q8IZ41

Also Known as RASEF_HUMAN, RASEF, RAB45

Binds predominantly GDP, and also GTP. Homodimer.

2PMY
EF-HAND DOMAIN OF HUMAN RASEF
RCSB/PDB
Inspect Structure
See all 3D Structures for RASEF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
740ENSG00000165105ENST00000376447ENSP00000365630Q8IZ41-1
189ENSG00000165105ENST00000340717ENSP00000345651Q8IZ41-2

Sub-cellular localization


UniProt: RASEF is active in the following subcellular-locations: cytoplasm, perinuclear region.
GO terms: RASEF is active in the following subcellular-locations: cytosol, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RASEF has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-74, NCI-H2110, SNU-620

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, GM12878, SK-N-SH_RA

(see details)

3D Structures


For RASEF there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RASEF has been screened with compounds ( bioactivities). (see details)