Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

REM2 (Q8IYK8) - Overview - Molecular Target Synopsis

Protein


REM2, GTP-binding protein REM 2
UniProt Q8IYK8

Also Known as REM2_HUMAN, REM2

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.

3CBQ
CRYSTAL STRUCTURE OF THE HUMAN REM2 GTPASE WITH BOUND GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for REM2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
340ENSG00000139890ENST00000267396ENSP00000267396Q8IYK8-1
221ENSG00000139890ENST00000536884ENSP00000442774Q8IYK8-2

Sub-cellular localization


UniProt: REM2 is active in the following subcellular-locations: cell membrane.
GO terms: REM2 is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project REM2 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, HS578T, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LN-18, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For REM2 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis