Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NIM1K (Q8IY84) - Overview - Molecular Target Synopsis

Protein


NIM1K, Serine/threonine-protein kinase NIM1
Enzyme Classification 2.7.11.1
UniProt Q8IY84

Also Known as NIM1_HUMAN, NIM1K, NIM1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
436ENSG00000177453ENST00000512796, ENST00000326035ENSP00000420849, ENSP00000313572Q8IY84-1

Sub-cellular localization


GO terms: NIM1K is active in the following subcellular-locations: cytoplasm, nucleotide-activated protein kinase complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NIM1K has gain in 38 cell-lines, loss in 0 cell-lines and no signal in 967 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2106, CPC-N, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


NIM1K was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, PCI30. (see details)

3D Structures


At greater than 35% identity similarity to NIM1K there are:
96 structures (171 chains) solved
66 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

NIM1K is solved in complex with the approved drug(s):

XIN/NINTEDANIB (5MAF_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NIM1K has been screened with 104 compounds (110 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)