Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NIM1K (Q8IY84) - Overview - Molecular Target Synopsis


NIM1K, Serine/threonine-protein kinase NIM1
Enzyme Classification
UniProt Q8IY84

Also Known as NIM1_HUMAN, NIM1K, NIM1

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
436ENSG00000177453ENST00000512796, ENST00000326035ENSP00000420849, ENSP00000313572Q8IY84-1

Sub-cellular localization

GO terms: NIM1K is active in the following subcellular-locations: cytoplasm, nucleotide-activated protein kinase complex, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NIM1K has gain in 38 cell-lines, loss in 0 cell-lines and no signal in 967 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2106, CPC-N, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference

NIM1K was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, PCI30. (see details)

3D Structures

At greater than 35% identity similarity to NIM1K there are:
96 structures (171 chains) solved
66 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

NIM1K is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

NIM1K has been screened with 108 compounds (114 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)