Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FTSJ3 (Q8IY81) - Overview - Molecular Target Synopsis

Protein


FTSJ3, pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Enzyme Classification 2.1.1.-
UniProt Q8IY81

Also Known as SPB1_HUMAN, FTSJ3

RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). Interacts with NIP7.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus, preribosome, preribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FTSJ3 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, OVCAR_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HUP-T3, SK-N-FI, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to FTSJ3 there are:
4 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis