FTSJ3 (Q8IY81) - Overview - Molecular Target Synopsis
FTSJ3, pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Enzyme Classification 2.1.1.-
Also Known as SPB1_HUMAN, FTSJ3
RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). Interacts with NIP7.
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UniProt: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus, preribosome, preribosome.