Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

FTSJ3 (Q8IY81) - Overview - Molecular Target Synopsis


FTSJ3, pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Enzyme Classification 2.1.1.-
UniProt Q8IY81

Also Known as SPB1_HUMAN, FTSJ3

RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973). Interacts with NIP7.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: FTSJ3 is active in the following subcellular-locations: nucleolus, nucleus, preribosome, preribosome.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project FTSJ3 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: CAKI_1, OVCAR_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HUP-T3, SK-N-FI, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures

At greater than 35% identity similarity to FTSJ3 there are:
4 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis