Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

LMTK2 (Q8IWU2) - Overview - Molecular Target Synopsis


LMTK2, Serine/threonine-protein kinase LMTK2
Enzyme Classification
UniProt Q8IWU2

Also Known as LMTK2_HUMAN, LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2

Phosphorylates PPP1C, phosphorylase b and CFTR. Interacts with PPP1C and inhibitor-2.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

Gene Copy Number Variation

In COSMIC - Cell Lines Project LMTK2 has gain in 11 cell-lines, loss in 2 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: TK_10, HS578T, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, NCI-H1623, AsPC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

RNA Interference

LMTK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: JIMT1, MDAMB134VI. (see details)

Screening and Chemistry

LMTK2 has been screened with compounds ( bioactivities). (see details)