Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LMTK2 (Q8IWU2) - Overview - Molecular Target Synopsis

Protein


LMTK2, Serine/threonine-protein kinase LMTK2
Enzyme Classification 2.7.11.1
UniProt Q8IWU2

Also Known as LMTK2_HUMAN, LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2

Phosphorylates PPP1C, phosphorylase b and CFTR. Interacts with PPP1C and inhibitor-2.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1503ENSG00000164715ENST00000297293ENSP00000297293Q8IWU2-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project LMTK2 has gain in 11 cell-lines, loss in 2 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, HS578T, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, NCI-H1623, AsPC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

RNA Interference


LMTK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: JIMT1, MDAMB134VI. (see details)


Screening and Chemistry


LMTK2 has been screened with compounds ( bioactivities). (see details)