BRSK2 (Q8IWQ3) - Overview - Molecular Target Synopsis
BRSK2, Serine/threonine-protein kinase BRSK2
Enzyme Classification 188.8.131.52
Also Known as BRSK2_HUMAN, BRSK2, C11orf7, PEN11B, SADA, STK29
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. Interacts with FZR1, a regulatory subunit of the APC ubiquitin ligase complex. Interacts with COPS5. Interacts with PAK1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|696||ENSG00000174672||ENST00000526678, ENST00000308230||ENSP00000433370, ENSP00000310805||Q8IWQ3-4|
|674||ENSG00000174672||ENST00000531197, ENST00000529433||ENSP00000431152, ENSP00000433684||Q8IWQ3-2|
UniProt: BRSK2 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, endoplasmic reticulum, microtubule organizing center, perinuclear region.
GO terms: BRSK2 is active in the following subcellular-locations: centrosome, cytoplasm, distal axon, endoplasmic reticulum, nucleus, perinuclear region of cytoplasm.