Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TEX14 (Q8IWB6) - Overview - Molecular Target Synopsis

Protein


TEX14, Inactive serine/threonine-protein kinase TEX14
UniProt Q8IWB6

Also Known as TEX14_HUMAN, TEX14, SGK307

Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101.

3WUT
13 RESIDUE FRAGMENT OF
INACTIVE SERINE/THREONINE-PROTEIN KINASE TEX14
IN THE STRUCTURE OF
STRUCTURE BASIS OF INACTIVATING CELL ABSCISSION
RCSB/PDB
Inspect Structure
See all 3D Structures for TEX14

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TEX14 is active in the following subcellular-locations: centromere, chromosome, cytoplasm, kinetochore, midbody.
GO terms: TEX14 is active in the following subcellular-locations: cell, condensed chromosome kinetochore, cytoplasm, extracellular exosome, intercellular bridge, kinetochore, midbody.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TEX14 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2911, KMM-1, A4/Fuk

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


TEX14 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAOV3, SKGT4. (see details)

3D Structures


For TEX14 there are:
2 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis