Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPNS2 (Q8IVW8) - Overview - Molecular Target Synopsis

Protein


SPNS2, Protein spinster homolog 2
UniProt Q8IVW8

Also Known as SPNS2_HUMAN, SPNS2

Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
549ENSG00000183018ENST00000329078ENSP00000333292Q8IVW8-1
282ENSG00000183018ENST00000571386ENSP00000461410

Sub-cellular localization


UniProt: SPNS2 is active in the following subcellular-locations: membrane.
GO terms: SPNS2 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPNS2 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, ACHN, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RERF-LC-KJ, SW 1417, SNU-449

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, CD34-positive mobilized cell, SK-N-SH

(see details)