Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDKL3 (Q8IVW4) - Overview - Molecular Target Synopsis

Protein


CDKL3, Cyclin-dependent kinase-like 3
Enzyme Classification 2.7.11.22
UniProt Q8IVW4

Also Known as CDKL3_HUMAN, CDKL3, NKIAMRE


3ZDU
CRYSTAL STRUCTURE OF THE HUMAN CDKL3 KINASE DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for CDKL3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CDKL3 is active in the following subcellular-locations: cytoplasm.
GO terms: CDKL3 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDKL3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, NCI_H226, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H322T, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CDKL3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL51, OVTOKO. (see details)

3D Structures


For CDKL3 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDKL3 has been screened with 84 compounds (90 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)