Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL17A,ARL17B (Q8IVW1) - Overview - Molecular Target Synopsis

Protein


ARL17A,ARL17B, ADP-ribosylation factor-like protein 17
UniProt Q8IVW1

Also Known as ARL17_HUMAN, ARL17A,ARL17B, ARL17P1, ARF1P2, ARL17A

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL17A,ARL17B is active in the following subcellular-locations: golgi apparatus.
GO terms: ARL17A,ARL17B is active in the following subcellular-locations: Golgi apparatus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL17A,ARL17B has gain in 4 cell-lines, loss in 2 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


At greater than 50% identity similarity to ARL17A,ARL17B there are:
63 structures (141 chains) solved
52 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL17A,ARL17B has been screened with compounds ( bioactivities). (see details)