KSR1 (Q8IVT5) - Overview - Molecular Target Synopsis
KSR1, Kinase suppressor of Ras 1
Also Known as KSR1_HUMAN, KSR1, KSR
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself. Interacts with HSP90AA1/HSP90, YWHAE/14-3-3, CDC37, MAP2K1/MEK-1 and MAP2K2/MEK-2 (PubMed:10409742). Interacts with MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487). Interacts with AKAP13 and BRAF (PubMed:21102438). Identified in a complex with AKAP13, MAP2K1 and BRAF.
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UniProt: KSR1 is active in the following subcellular-locations: cell membrane, cell projection, cytoplasm, endoplasmic reticulum membrane, membrane, ruffle membrane.
GO terms: KSR1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, protein-containing complex, ruffle membrane.