Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

P3H2 (Q8IVL5) - Overview - Molecular Target Synopsis

Protein


P3H2, Prolyl 3-hydroxylase 2
Enzyme Classification 1.14.11.7
UniProt Q8IVL5

Also Known as P3H2_HUMAN, P3H2, LEPREL1, MLAT4

Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:18487197). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1 (PubMed:18487197). Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline (PubMed:18487197). Has no activity on substrates that lack 4-hydroxyproline in the third position (PubMed:18487197).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: P3H2 is active in the following subcellular-locations: endoplasmic reticulum, golgi apparatus, sarcoplasmic reticulum.
GO terms: P3H2 is active in the following subcellular-locations: basement membrane, endoplasmic reticulum, endoplasmic reticulum lumen, Golgi apparatus, sarcoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project P3H2 has gain in 11 cell-lines, loss in 4 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 675.T, NCI-H2804, HCC1319

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, IMR-90, NHEK

(see details)