Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP4K3 (Q8IVH8) - Overview - Molecular Target Synopsis

Protein


MAP4K3, Mitogen-activated protein kinase kinase kinase kinase 3
Enzyme Classification 2.7.11.1
UniProt Q8IVH8

Also Known as M4K3_HUMAN, MAP4K3, RAB8IPL1

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation.

5J5T
GLK CO-CRYSTAL STRUCTURE WITH AMINOPYRROLOPYRIMIDINE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for MAP4K3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MAP4K3 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP4K3 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: IGROV1, OVCAR_5, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H727, GTL-16, RT4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

RNA Interference


MAP4K3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVISE, COV362. (see details)

3D Structures


For MAP4K3 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP4K3 has been screened with 120 compounds (159 bioactivities), 20 compounds have bioactivities that show binding affinity of <= 500nM (29 bioactivities). (see details)