Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

VRK3 (Q8IV63) - Overview - Molecular Target Synopsis

Protein


VRK3, Inactive serine/threonine-protein kinase VRK3
UniProt Q8IV63

Also Known as VRK3_HUMAN, VRK3

Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Interacts with DUSP3 (By similarity). Interacts with RAN.

2JII
STRUCTURE OF VACCINIA RELATED KINASE 3
RCSB/PDB
Inspect Structure
See all 3D Structures for VRK3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: VRK3 is active in the following subcellular-locations: nucleus.
GO terms: VRK3 is active in the following subcellular-locations: cytoplasm, intracellular membrane-bounded organelle, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project VRK3 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, LOXIMVI, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TMD8, TK, RI-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

RNA Interference


VRK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: TE6, T47D. (see details)

3D Structures


For VRK3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


VRK3 has been screened with compounds ( bioactivities). (see details)