Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLD3 (Q8IV08) - Overview - Molecular Target Synopsis

Protein


PLD3, Phospholipase D3
Enzyme Classification 3.1.4.4
UniProt Q8IV08

Also Known as PLD3_HUMAN, PLD3

May be involved in APP processing. Interacts with APP.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLD3 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: PLD3 is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLD3 has gain in 11 cell-lines, loss in 0 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_3, OVCAR_4, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, RERF-GC-1B, KLE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, A549

(see details)


Screening and Chemistry


PLD3 has been screened with compounds ( bioactivities). (see details)