Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RELL1 (Q8IUW5) - Overview - Molecular Target Synopsis

Protein


RELL1, RELT-like protein 1
UniProt Q8IUW5

Also Known as RELL1_HUMAN, RELL1

Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764). Induces apoptosis, when overexpressed (PubMed:19969290). Interacts with RELT, RELL2 and OXSR1 (PubMed:16389068). Interacts with PLSCR1 (PubMed:22052202).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
271ENSG00000181826ENST00000454158, ENST00000314117ENSP00000398778, ENSP00000313385Q8IUW5-1
254ENSG00000181826ENST00000512114ENSP00000424031

Sub-cellular localization


UniProt: RELL1 is active in the following subcellular-locations: cell membrane.
GO terms: RELL1 is active in the following subcellular-locations: integral component of membrane, microtubule cytoskeleton, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RELL1 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-1, NCI-H520, Hs 695T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, HUVEC

(see details)