Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHX4 (Q8IUS5) - Overview - Molecular Target Synopsis

Protein


EPHX4, Epoxide hydrolase 4
Enzyme Classification 3.3.-.-
UniProt Q8IUS5

Also Known as EPHX4_HUMAN, EPHX4, ABHD7, EH4, EPHXRP

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
362ENSG00000172031ENST00000370383ENSP00000359410Q8IUS5-1

Sub-cellular localization


UniProt: EPHX4 is active in the following subcellular-locations: membrane.
GO terms: EPHX4 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EPHX4 has gain in 6 cell-lines, loss in 3 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OvCA 432, TYK-nu.CP-r, NCI-H1915

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to EPHX4 there are:
4 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis