Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIOX2 (Q8IUF8) - Overview - Molecular Target Synopsis

Protein


RIOX2, Ribosomal oxygenase 2
Enzyme Classification 1.14.11.-
UniProt Q8IUF8

Also Known as RIOX2_HUMAN, RIOX2, MDIG, MINA, MINA53, NO52

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

4BU2
60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53) IN COMPLEX WITH NI(II) AND 2-OXOGLUTARATE (2OG)
RCSB/PDB
Inspect Structure
See all 3D Structures for RIOX2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIOX2 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RIOX2 is active in the following subcellular-locations: cytosol, nucleolus, nucleoplasm, nucleus, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIOX2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For RIOX2 there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis