RIOX2 (Q8IUF8) - Overview - Molecular Target Synopsis
RIOX2, Ribosomal oxygenase 2
Enzyme Classification 1.14.11.-
Also Known as RIOX2_HUMAN, RIOX2, MDIG, MINA, MINA53, NO52
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|465||ENSG00000170854||ENST00000333396, ENST00000394198||ENSP00000328251, ENSP00000377748||Q8IUF8-1|
|280||ENSG00000170854||ENST00000330299, ENST00000514314||ENSP00000327424, ENSP00000424955||Q8IUF8-2|
UniProt: RIOX2 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RIOX2 is active in the following subcellular-locations: cytosol, nucleolus, nucleoplasm, nucleus, transcription factor complex.