Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

CAMK1D (Q8IU85) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2JC6_A Calcium/calmodulin-dependent protein kinase type 1D Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 68.1 63.6 Yes Yes
2 empty 2.45 64 20.2 No No
3 empty 2.33 67.1 27.7 No No
4 empty 2.32 71 14.3 No No
5 empty 2.43 61.7 19.4 No No
6 empty 2.04 72.1 18.2 No No
7 empty 2.18 80.1 13.4 No No
8 empty 2.38 71.7 8.8 No No
9 empty 2.01 60.7 12.4 No No
10 empty 2.71 62 10 No No
2JC6_C Calcium/calmodulin-dependent protein kinase type 1D Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 67.4 63.2 Yes Yes
2 empty 2.49 68.8 19.7 No No
3 empty 2.49 65.6 27.1 No No
4 empty 2.43 69.3 16.2 No No
5 empty 1.89 74.4 10.1 No No
6 empty 1.91 62.3 15.8 No No
7 empty 2.49 73.5 7.2 No No
8 empty 2.49 71.2 7.3 No No
9 empty 2.14 60.4 8 No No
10 empty 2.61 67.3 8.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2JC6_A (3130318) Calcium/calmodulin-dependent protein kinase type 1D Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.3Å Yes Yes
2JC6_A (4254962) Calcium/calmodulin-dependent protein kinase type 1D Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
2JC6_C (4254962) Calcium/calmodulin-dependent protein kinase type 1D Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit (Homo Multimer) 2.3Å Yes Yes
Ligand-based Druggability Score: -0.6
Ligand-based Druggability Score Percentile: 73%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


CAMK1D is involved in 12 interactions in the network.


Druggability
Overall Druggability Percentile: 63.84
Druggability for Cancer Therapeutics: 60.76
Druggability for Other Therapeutics: 76.49
Cancer-Associated
Cancer-associated percentile : 62.23
Network Articulation Point
Is CAMK1D critical for communication in the network?


Detailed Graph Legend:Help