Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMK1D (Q8IU85) - Overview - Molecular Target Synopsis

Protein


CAMK1D, Calcium/calmodulin-dependent protein kinase type 1D
Enzyme Classification 2.7.11.17
UniProt Q8IU85

Also Known as KCC1D_HUMAN, CAMK1D, CAMKID

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

2JC6
CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE 1D
RCSB/PDB
Inspect Structure
See all 3D Structures for CAMK1D

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
385ENSG00000183049ENST00000378847ENSP00000368124Q8IU85-1
357ENSG00000183049ENST00000378845ENSP00000368122Q8IU85-2

Sub-cellular localization


UniProt: CAMK1D is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CAMK1D is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMK1D has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, A498, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, COR-L88, NCI-H345

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, NHLF, HMEC

(see details)

RNA Interference


CAMK1D was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCC1954, SKBR3. (see details)

3D Structures


For CAMK1D there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CAMK1D has been screened with 779 compounds (1458 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)