Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

arcB (Q8EVF5) - Overview - Molecular Target Synopsis

Protein


arcB, Ornithine carbamoyltransferase, catabolic
Enzyme Classification 2.1.3.3
UniProt Q8EVF5

Also Known as OTCC_MYCPE, arcB

nvolved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. Dodecamer (tetramer of trimers).

4AMU
STRUCTURE OF ORNITHINE CARBAMOYLTRANSFERASE FROM MYCOPLASMA PENETRANS WITH A P321 SPACE GROUP
RCSB/PDB
Inspect Structure
See all 3D Structures for arcB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
342Q8EVF5-1

Sub-cellular localization


UniProt: arcB is active in the following subcellular-locations: cytoplasm.
GO terms: arcB is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project arcB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For arcB there are:
2 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


arcB has been screened with compounds ( bioactivities). (see details)