Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Aldh4a1 (Q8CHT0) - Overview - Molecular Target Synopsis

Protein


Aldh4a1, Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Enzyme Classification 1.2.1.88
UniProt Q8CHT0

Also Known as AL4A1_MOUSE, Aldh4a1

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Homodimer.

4LGZ
STRUCTURE OF MOUSE 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1) COMPLEXED WITH ACETATE
RCSB/PDB
Inspect Structure
See all 3D Structures for Aldh4a1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
562Q8CHT0-1

Sub-cellular localization


UniProt: Aldh4a1 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: Aldh4a1 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Aldh4a1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Aldh4a1 there are:
9 structures (18 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis