Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Pgp (Q8CHP8) - Overview - Molecular Target Synopsis

Protein


Pgp, Glycerol-3-phosphate phosphatase
Enzyme Classification 3.1.3.21
UniProt Q8CHP8

Also Known as PGP_MOUSE, Pgp

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism (PubMed:26755581). Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear (PubMed:26755581, PubMed:24338473). In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP (PubMed:24338473). Homodimer.

4BKM
CRYSTAL STRUCTURE OF THE MURINE AUM (PHOSPHOGLYCOLATE PHOSPHATASE) CAPPING DOMAIN AS A FUSION PROTEIN WITH THE CATALYTIC CORE DOMAIN OF MURINE CHRONOPHIN (PYRIDOXAL PHOSPHATE PHOSPHATASE)
RCSB/PDB
Inspect Structure
See all 3D Structures for Pgp

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
321Q8CHP8-1

Sub-cellular localization


GO terms: Pgp is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Pgp has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Pgp there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis