Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Dusp28 (Q8BTR5) - Overview - Molecular Target Synopsis

Protein


Dusp28, Dual specificity phosphatase 28
Enzyme Classification 3.1.3.16
UniProt Q8BTR5

Also Known as DUS28_MOUSE, Dusp28

Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyrosine, even less activity with phosphothreonine and displays complete lack of activity with phosphoserine. The poor activity with phosphotyrosine may be due to steric hindrance by bulky amino acid sidechains that obstruct access to the active site. Monomer.

2HCM
CRYSTAL STRUCTURE OF MOUSE PUTATIVE DUAL SPECIFICITY PHOSPHATASE COMPLEXED WITH ZINC TUNGSTATE, NEW YORK STRUCTURAL GENOMICS CONSORTIUM
RCSB/PDB
Inspect Structure
See all 3D Structures for Dusp28

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
163Q8BTR5-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project Dusp28 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Dusp28 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Dusp28 has been screened with compounds ( bioactivities). (see details)