Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(Q89VT8) - Overview - Molecular Target Synopsis

Protein


, Amino acid--[acyl-carrier-protein] ligase 1
Enzyme Classification 6.2.1.n2
UniProt Q89VT8

Also Known as AACL1_BRADU

Catalyzes the ATP-dependent activation of L-glycine and its transfer to the phosphopantetheine prosthetic group covalently attached to the vicinal carrier protein bsr0959 of yet unknown function. May participate in nonribosomal peptide synthesis or related processes. L-alanine is a poor substrate whereas L-serine or D-amino acids are not substrates for ATP-dependent activation. Does not display tRNA aminoacylation activity. Homodimer.

4H2T
CRYSTAL STRUCTURE OF BRADYRHIZOBIUM JAPONICUM GLYCINE:[CARRIER PROTEIN] LIGASE COMPLEXED WITH COGNATE CARRIER PROTEIN AND AN ANALOGUE OF GLYCYL ADENYLATE
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
326Q89VT8-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
11 structures (22 chains) solved
11 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3MF2_A, 3MF2_B, 4H2S_A, 4H2S_B, 4H2V_A, 4H2V_B, 4H2W_B).

(see details)
Molecular Target 3D Synopsis