HIPK1 (Q86Z02) - Overview - Molecular Target Synopsis
HIPK1, Homeodomain-interacting protein kinase 1
Enzyme Classification 220.127.116.11
Also Known as HIPK1_HUMAN, HIPK1, KIAA0630, MYAK, NBAK2
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|1210||ENSG00000163349||ENST00000369558, ENST00000426820||ENSP00000358571, ENSP00000407442||Q86Z02-1|
|816||ENSG00000163349||ENST00000369553, ENST00000406344||ENSP00000358566, ENSP00000384960||Q86Z02-4|
UniProt: HIPK1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: HIPK1 is active in the following subcellular-locations: centrosome, cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, PML body.