Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYLK4 (Q86YV6) - Overview - Molecular Target Synopsis

Protein


MYLK4, Myosin light chain kinase family member 4
Enzyme Classification 2.7.11.1
UniProt Q86YV6

Also Known as MYLK4_HUMAN, MYLK4, SGK085


2X4F
THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAIN KINASE LOC340156.
RCSB/PDB
Inspect Structure
See all 3D Structures for MYLK4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
388ENSG00000145949ENST00000268446ENSP00000268446
388ENSG00000145949ENST00000274643ENSP00000274643Q86YV6-1
388Q86YV6-2

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYLK4 has gain in 3 cell-lines, loss in 3 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M2, OCI-AML2, SET-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


MYLK4 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MCF7, SUM44. (see details)

3D Structures


For MYLK4 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MYLK4 has been screened with 117 compounds (156 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)