Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB43 (Q86YS6) - Overview - Molecular Target Synopsis

Protein


RAB43, Ras-related protein Rab-43
UniProt Q86YS6

Also Known as RAB43_HUMAN, RAB43, RAB41

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

2HUP
CRYSTAL STRUCTURE OF HUMAN RAB43 IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB43

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB43 is active in the following subcellular-locations: cytoplasmic vesicle, golgi apparatus, phagosome, phagosome membrane, trans-golgi network, trans-golgi network membrane.
GO terms: RAB43 is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, Golgi apparatus, Golgi membrane, phagocytic vesicle, phagocytic vesicle membrane, trans-Golgi network membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB43 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_62, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, SK-N-FI, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RAB43 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB43 has been screened with compounds ( bioactivities). (see details)