Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

BPHL (Q86WA6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2OCL_A Valacyclovir hydrolase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 76.9 24.7 Yes Yes
2 empty 2.3 63.4 18.3 No No
3 empty 1.98 70 20.4 No No
4 empty 2.28 62.5 14 No No
5 empty 2.52 59.2 19.5 No No
6 empty 2.71 64.9 15.8 No No
7 empty 2.17 66 8.6 No No
8 empty 2.44 68.8 10.7 No No
9 empty 2.52 66.7 6.6 No No
10 empty 1.7 55.7 10.5 No No
2OCG_A Valacyclovir hydrolase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 76.8 26.7 Yes Yes
2 empty 2.38 61.8 19.3 No No
3 empty 2.34 58 17.9 No No
4 empty 2.08 70.5 17.1 No No
5 empty 1.96 55.3 10.4 No No
6 empty 2.58 61.4 12.4 No No
7 empty 2.53 55.9 12 No No
8 empty 2.33 62.3 8.4 No No
9 empty 2.59 68.5 11.5 No No
10 empty 2.65 63.4 11.9 No No
2OCK_A Valacyclovir hydrolase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 74.6 24.9 Yes Yes
2 empty 2.11 61 15.5 No No
3 empty 2.31 62.2 15.8 No No
4 empty 2.09 71 16.7 No No
5 empty 2.52 65.5 11.5 No No
6 empty 2.48 57.9 13.6 No No
7 empty 2.78 65.1 12.8 No No
8 empty 2.45 64.9 11 No No
9 empty 2.19 58 9.4 No No
10 empty 2.87 61.8 6.8 No No
2OCI_A Valacyclovir hydrolase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.33 80.6 26.1 Yes Yes
2 empty 2.36 63 22.5 No No
3 empty 2.32 57.8 13.2 No No
4 empty 2.1 69.5 18.2 No No
5 empty 2.02 62.8 11.9 No No
6 empty 1.81 52.5 11 No No
7 empty 2.61 62.8 12.2 No No
8 empty 2.56 62.7 13.1 No No
9 empty 2.23 65.6 8.3 No No
10 empty 2.52 61.6 9.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2OCG_A (3160423) Valacyclovir hydrolase alpha/beta-Hydrolases, alpha/beta-Hydrolases, UNMATCHED 1.75Å Yes Yes
2OCI_A (3160425) Valacyclovir hydrolase alpha/beta-Hydrolases, alpha/beta-Hydrolases, UNMATCHED 1.9Å Yes Yes
2OCK_A (3160426) Valacyclovir hydrolase alpha/beta-Hydrolases, alpha/beta-Hydrolases, UNMATCHED 1.85Å Yes Yes
2OCL_A (3160427) Valacyclovir hydrolase alpha/beta-Hydrolases, alpha/beta-Hydrolases, UNMATCHED 1.9Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score