Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BPHL (Q86WA6) - Overview - Molecular Target Synopsis

Protein


BPHL, Valacyclovir hydrolase
Enzyme Classification 3.1.-.-
UniProt Q86WA6

Also Known as BPHL_HUMAN, BPHL, MCNAA

Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.

2OCG
CRYSTAL STRUCTURE OF HUMAN VALACYCLOVIR HYDROLASE
RCSB/PDB
Inspect Structure
See all 3D Structures for BPHL

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: BPHL is active in the following subcellular-locations: mitochondrial outer membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BPHL has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, SK_MEL_5, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, NCI-H522, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, IMR-90

(see details)

3D Structures


For BPHL there are:
4 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BPHL has been screened with 4 compounds (15 bioactivities). (see details)