BPHL (Q86WA6) - Overview - Molecular Target Synopsis
BPHL, Valacyclovir hydrolase
Enzyme Classification 3.1.-.-
Also Known as BPHL_HUMAN, BPHL, MCNAA
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|274||ENSG00000137274||ENST00000380375, ENST00000434640||ENSP00000369734, ENSP00000390472||Q86WA6-2|
GO terms: BPHL is active in the following subcellular-locations: mitochondrial outer membrane, mitochondrion.