Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPFIBP1 (Q86W92) - Overview - Molecular Target Synopsis

Protein


PPFIBP1, Liprin-beta-1
UniProt Q86W92

Also Known as LIPB1_HUMAN, PPFIBP1, KIAA1230

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: PPFIBP1 is active in the following subcellular-locations: cytosol, focal adhesion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPFIBP1 has gain in 23 cell-lines, loss in 4 cell-lines and no signal in 978 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, SR, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, OAW28, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to PPFIBP1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis