Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PPFIBP1 (Q86W92) - Overview - Molecular Target Synopsis


PPFIBP1, Liprin-beta-1
UniProt Q86W92

Also Known as LIPB1_HUMAN, PPFIBP1, KIAA1230

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: PPFIBP1 is active in the following subcellular-locations: cytosol, focal adhesion, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PPFIBP1 has gain in 23 cell-lines, loss in 4 cell-lines and no signal in 978 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_28, SR, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NIH:OVCAR-3, OAW28, SW 480

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures

At greater than 90% identity similarity to PPFIBP1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis