Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COMTD1 (Q86VU5) - Overview - Molecular Target Synopsis

Protein


COMTD1, Catechol O-methyltransferase domain-containing protein 1
Enzyme Classification 2.1.1.-
UniProt Q86VU5

Also Known as CMTD1_HUMAN, COMTD1

Putative O-methyltransferase. Homodimer.

2AVD
CRYSTAL STRUCTURE OF HUMAN CATECHOL-O-METHYLTRANSFERASE DOMAIN CONTAINING 1
RCSB/PDB
Inspect Structure
See all 3D Structures for COMTD1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
262ENSG00000165644ENST00000372538ENSP00000361616Q86VU5-1
261ENSG00000165644ENST00000469299ENSP00000473626

Sub-cellular localization


UniProt: COMTD1 is active in the following subcellular-locations: membrane.
GO terms: COMTD1 is active in the following subcellular-locations: integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COMTD1 has gain in 7 cell-lines, loss in 2 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, MCF7, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, OVSAHO, LS1034

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, K562

(see details)

3D Structures


For COMTD1 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis