Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SATL1 (Q86VE3) - Overview - Molecular Target Synopsis

Protein


SATL1, Spermidine/spermine N(1)-acetyltransferase-like protein 1
Enzyme Classification 2.3.1.-
UniProt Q86VE3

Also Known as SATL1_HUMAN, SATL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: SATL1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SATL1 has gain in 2 cell-lines, loss in 31 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, PC_3, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to SATL1 there are:
12 structures (26 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SATL1 has been screened with compounds ( bioactivities). (see details)