Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PIM3 (Q86V86) - Overview - Molecular Target Synopsis


PIM3, Serine/threonine-protein kinase pim-3
Enzyme Classification
UniProt Q86V86

Also Known as PIM3_HUMAN, PIM3

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation. Interacts with SOCS6 (By similarity).

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: PIM3 is active in the following subcellular-locations: cytoplasm.
GO terms: PIM3 is active in the following subcellular-locations: cytoplasm, cytosol.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PIM3 has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: M14, SK_MEL_5, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: FaDu, NCI-H1573, COLO 699

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, SK-N-SH, K562

(see details)

RNA Interference

PIM3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H358, OE19. (see details)

3D Structures

At greater than 50% identity similarity to PIM3 there are:
158 structures (166 chains) solved
154 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

PIM3 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PIM3 has been screened with 2288 compounds (3283 bioactivities), 1201 compounds have bioactivities that show binding affinity of <= 500nM (1325 bioactivities). (see details)