Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADIPOR2 (Q86V24) - Overview - Molecular Target Synopsis

Protein


ADIPOR2, Adiponectin receptor protein 2
UniProt Q86V24

Also Known as PAQR2_HUMAN, ADIPOR2, PAQR2

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels. May form homooligomers and heterooligomers with ADIPOR1 (PubMed:12802337). Interacts with APPL2 (via BAR domain); ADIPOQ dissociates this interaction.

5LWY
REVISED CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR 2 IN COMPLEX WITH A C18 FREE FATTY ACID
RCSB/PDB
Inspect Structure
See all 3D Structures for ADIPOR2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
386ENSG00000006831ENST00000357103ENSP00000349616Q86V24-1

Sub-cellular localization


UniProt: ADIPOR2 is active in the following subcellular-locations: cell membrane.
GO terms: ADIPOR2 is active in the following subcellular-locations: integral component of membrane, intrinsic component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADIPOR2 has gain in 10 cell-lines, loss in 2 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, ACHN, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, DMS 53, EBC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, HMEC

(see details)

3D Structures


For ADIPOR2 there are:
4 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis