Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AACS (Q86V21) - Overview - Molecular Target Synopsis

Protein


AACS, Acetoacetyl-CoA synthetase
Enzyme Classification 6.2.1.16
UniProt Q86V21

Also Known as AACS_HUMAN, AACS, ACSF1

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AACS is active in the following subcellular-locations: cytoplasm, cytosol.
GO terms: AACS is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AACS has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, NCI_H460, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, NCI-H209, HUP-T3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to AACS there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis