Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAA40 (Q86UY6) - Overview - Molecular Target Synopsis

Protein


NAA40, N-alpha-acetyltransferase 40
Enzyme Classification 2.3.1.257
UniProt Q86UY6

Also Known as NAA40_HUMAN, NAA40, NAT11, PATT1

N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism.

4U9V
CRYSTAL STRUCTURE OF NATD (NAA40P) BOUND TO ACETYL COA
RCSB/PDB
Inspect Structure
See all 3D Structures for NAA40

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAA40 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NAA40 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA40 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, NCI-H1155, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For NAA40 there are:
2 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis