Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK32C (Q86UX6) - Overview - Molecular Target Synopsis

Protein


STK32C, Serine/threonine-protein kinase 32C
Enzyme Classification 2.7.11.1
UniProt Q86UX6

Also Known as ST32C_HUMAN, STK32C, YANK3

Isoforms / Transcripts (Protein Coding)


Gene Copy Number Variation


In COSMIC - Cell Lines Project STK32C has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, COLO205, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BEN, VMRC-LCD, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HeLa-S3

(see details)

RNA Interference


STK32C was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, SKOV3. (see details)

3D Structures


At greater than 50% identity similarity to STK32C there are:
1 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK32C has been screened with 129 compounds (168 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)