Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK32C (Q86UX6) - Overview - Molecular Target Synopsis


STK32C, Serine/threonine-protein kinase 32C
Enzyme Classification
UniProt Q86UX6

Also Known as ST32C_HUMAN, STK32C, YANK3

Isoforms / Transcripts (Protein Coding)

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK32C has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_OV_3, COLO205, A549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BEN, VMRC-LCD, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, HeLa-S3

(see details)

RNA Interference

STK32C was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: BXPC3, SKOV3. (see details)

3D Structures

At greater than 50% identity similarity to STK32C there are:
1 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK32C has been screened with 129 compounds (168 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)