Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA13 (Q86UQ4) - Overview - Molecular Target Synopsis

Protein


ABCA13, ATP-binding cassette sub-family A member 13
UniProt Q86UQ4

Also Known as ABCAD_HUMAN, ABCA13

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA13 is active in the following subcellular-locations: membrane.
GO terms: ABCA13 is active in the following subcellular-locations: azurophil granule membrane, integral component of membrane, intracellular membrane-bounded organelle, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA13 has gain in 11 cell-lines, loss in 2 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SU-DHL-1, SR, SCC-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ABCA13 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA13 has been screened with compounds ( bioactivities). (see details)