Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCA12 (Q86UK0) - Overview - Molecular Target Synopsis

Protein


ABCA12, ATP-binding cassette sub-family A member 12
UniProt Q86UK0

Also Known as ABCAC_HUMAN, ABCA12, ABC12

Probable transporter involved in lipid homeostasis.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCA12 is active in the following subcellular-locations: membrane.
GO terms: ABCA12 is active in the following subcellular-locations: cytoplasm, cytosol, epidermal lamellar body, integral component of membrane, intracellular membrane-bounded organelle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCA12 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, T47D, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-361, YMB-1, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 35% identity similarity to ABCA12 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCA12 has been screened with compounds ( bioactivities). (see details)